Research ArticleDengue

Virus-specific T lymphocytes home to the skin during natural dengue infection

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Science Translational Medicine  11 Mar 2015:
Vol. 7, Issue 278, pp. 278ra35
DOI: 10.1126/scitranslmed.aaa0526

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Getting under dengue virus’s skin

Dengue virus infection is transmitted by mosquitoes, suggesting that a vaccine targeting the immune response to the skin could have protective effects. Rivino et al. examined individuals with natural dengue infection to determine whether skin-mediated immunity indeed contributes to the fight against dengue. They found that dengue infection induced highly activated CD8+ T cells that express the skin-homing marker cutaneous lymphocyte-associated antigen (CLA). CLA expression by these cells correlated with their ability to traffic to the skin during dengue infection. Notably, CLA was not up-regulated in bystander HCMV-restricted cells in these individuals, suggesting that the skin-targeted homing is pathogen-specific. These data support a role for skin-directed immunosurveillance against dengue and reinforce a skin-targeted vaccine strategy for this virus.