Research ArticleLUNG INJURY

Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting

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Science Translational Medicine  11 Mar 2015:
Vol. 7, Issue 278, pp. 278ra32
DOI: 10.1126/scitranslmed.3010283

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Exercising away lung injury

The benefits of exercise for healthy people are undisputed, but recent evidence suggests that exercise may have its place even among the sickest patients in the intensive care unit. New findings by Files et al. help explain these observations by using mouse models to find a mechanistic link between exercise and benefits in the acute respiratory distress syndrome, which they also confirm in human patients with respiratory failure who receive therapeutic exercise. The benefits of exercise in this setting include attenuation of muscle wasting as well as decreased lung inflammation. Although these improvements are both linked to exercise, they occur by different mechanisms, suggesting potential future approaches for more directed therapeutic intervention.