Vol 7, Issue 277
Gene therapy with lentiviral vectors targeting transgene expression to hepatocytes provides stable reconstitution of clotting activity in dogs with hemophilia B and does not show genotoxicity in tumor-prone mice.
By cross-linking fibrin, intravenously injected factor XIII–inspired hemostatic polymers stabilize clots and reduce bleeding in a rat model of trauma and fluid resuscitation.
Respiratory hyperoxia stimulates lung tumor regression by promoting T cell infiltration into the tumors and decreasing immunosuppression.
- Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction
GRK2 inhibition with paroxetine improves cardiac function independent of its central nervous system effects.