25 February 2015
Vol 7, Issue 276

About The Cover

Cover image expansion

ONLINE COVER Get the BugFACS! IgA antibody binds to gut microbes preventing them from leaving the gut. A method to identify these IgA-targeted bacteria called BugFACs has now been used to pinpoint gut microbes in malnourished Malawian children that contribute to severe gut enteropathy (Kau et al.). Transplanting these IgA-targeted microbes from undernourished children into germ-free mice fed the same nutrient-poor diet induced gut enteropathy in the mice as shown by staining (red) of the mouse intestine (pictured) for a marker of leakiness. [IMAGE COURTESY OF A. KAU, T.-C. LIU, AND J. PLANER, WASHINGTON UNIVERSITY]