Research ArticleTransplantation

In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells

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Science Translational Medicine  04 Feb 2015:
Vol. 7, Issue 273, pp. 273ra13
DOI: 10.1126/scitranslmed.3010314

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Sealing T cell fate

Clinical trials are a relatively untapped source of experimental data that can be leveraged to explore both basic and pathological biology in humans. Now, Biasco et al. take advantage of two different gene therapy trials for inherited immunodeficiency to track in the long term T cell fate in humans. They find that the recently described T memory stem cells (TSCM) are able to persist and preserve their precursor potential in human recipients for up to 12 years after genetic correction and infusion into patients. The safety and long-term survival of these cells not only strengthen our knowledge of human immunology but also support the use of TSCM cells for adoptive immunotherapy.