Research ArticleImmunology

mTOR inhibition improves immune function in the elderly

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Science Translational Medicine  24 Dec 2014:
Vol. 6, Issue 268, pp. 268ra179
DOI: 10.1126/scitranslmed.3009892

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mTOR and Human Aging

Inhibition of mTOR signaling extends life span and delays the onset of aging-related diseases in all species studied to date. These findings suggest that the mTOR pathway regulates aging. However, it is unknown if mTOR inhibition has beneficial effects on aging in humans. To begin to address this question, Mannick et al. evaluated the effects of the mTOR inhibitor RAD001 on the decline in immune function that occurs during aging in humans. Their findings suggest that RAD001 improved immune function in elderly volunteers as assessed by response to influenza vaccination. It remains to be determined whether mTOR inhibition improves additional aging-related conditions in humans.