Contents

24 December 2014
Vol 6, Issue 268

About The Cover

Cover image expansion

ONLINE COVER Plotting a Better Understanding of Cancer. Janus, the Roman god of beginnings and endings, with faces that look to both the future and the past, is a fitting image for this last journal issue of the calendar year. Janus also makes an appearance in a new article by Killian and co-authors, but for a more scientific purpose. In this research article, the authors identify an epigenetic mechanism for the inactivation of a gene called SDHC in gastrointestinal stromal tumors, helping to provide a unifying explanation for the etiology of this cancer. One of the tools the authors use to analyze tumor methylation and draw connections is a Janus plot, which shows the patterns of methylation and gene expression radiating outward from a line representing the genome sequence, presenting a visual connection between the two types of data. [CREDIT: P. SHERWOOD/PAT SHERWOOD ART]