Research ArticleANTIBODY THERAPEUTICS
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
- Y. Joy Yu1,*,
- Jasvinder K. Atwal1,*,
- Yin Zhang2,
- Raymond K. Tong3,
- Kristin R. Wildsmith4,
- Christine Tan2,
- Nga Bien-Ly1,
- Maria Hersom1,
- Janice A. Maloney1,
- William J. Meilandt1,
- Daniela Bumbaca4,
- Kapil Gadkar4,
- Kwame Hoyte5,
- Wilman Luk5,
- Yanmei Lu5,
- James A. Ernst3,
- Kimberly Scearce-Levie1,
- Jessica A. Couch4,
- Mark S. Dennis2 and
- Ryan J. Watts1,†
- 1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 2Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.
- 3Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
- 4Development Sciences, Genentech Inc., South San Francisco, CA 94080, USA.
- 5Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.
- ↵†Corresponding author. E-mail: rwatts{at}gene.com
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Science Translational Medicine 05 Nov 2014:
Vol. 6, Issue 261, pp. 261ra154
DOI: 10.1126/scitranslmed.3009835