Research ArticleANTIBODY THERAPEUTICS

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

See allHide authors and affiliations

Science Translational Medicine  05 Nov 2014:
Vol. 6, Issue 261, pp. 261ra154
DOI: 10.1126/scitranslmed.3009835

Article Information

vol. 6 no. 261 261ra154

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 18, 2014
  • Accepted for publication October 9, 2014

Author Information

  1. Y. Joy Yu1,*,
  2. Jasvinder K. Atwal1,*,
  3. Yin Zhang2,
  4. Raymond K. Tong3,
  5. Kristin R. Wildsmith4,
  6. Christine Tan2,
  7. Nga Bien-Ly1,
  8. Maria Hersom1,
  9. Janice A. Maloney1,
  10. William J. Meilandt1,
  11. Daniela Bumbaca4,
  12. Kapil Gadkar4,
  13. Kwame Hoyte5,
  14. Wilman Luk5,
  15. Yanmei Lu5,
  16. James A. Ernst3,
  17. Kimberly Scearce-Levie1,
  18. Jessica A. Couch4,
  19. Mark S. Dennis2 and
  20. Ryan J. Watts1,
  1. 1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  2. 2Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.
  3. 3Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
  4. 4Development Sciences, Genentech Inc., South San Francisco, CA 94080, USA.
  5. 5Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.
  1. Corresponding author. E-mail: rwatts{at}gene.com
    • * These authors contributed equally to this work.

    Altmetric

    Article usage

    Article usage: November 2014 to September 2018

    AbstractFullPdf
    Nov 2014377647851372
    Dec 20142502207327
    Jan 20152823228460
    Feb 201594857113
    Mar 201595170110
    Apr 20158384398
    May 201577837101
    Jun 20155004177
    Jul 20153575079
    Aug 2015955077
    Sep 20151196795
    Oct 2015139100128
    Nov 20153875103
    Dec 20151824786
    Jan 20167745191
    Feb 20165913570
    Mar 20168286267
    Apr 20167145693
    May 20167876369
    Jun 20164284759
    Jul 20163163051
    Aug 20163464462
    Sep 20164104283
    Oct 20163862548
    Nov 20162922647
    Dec 20163124648
    Jan 20172794858
    Feb 20172093543
    Mar 20173694061
    Apr 20172791966
    May 20172172542
    Jun 20172112544
    Jul 20172052945
    Aug 20172551845
    Sep 20172092751
    Oct 20172393566
    Nov 20173284353
    Dec 20172062836
    Jan 20182133662
    Feb 20181923044
    Mar 20181952858
    Apr 20182274151
    May 20182352949
    Jun 20182234868
    Jul 20181842234
    Aug 2018974742
    Sep 201856169