Research ArticleNeuroscience
Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia
- David N. Bochner1,*,
- Richard W. Sapp1,*,
- Jaimie D. Adelson1,
- Siyu Zhang2,
- Hanmi Lee1,
- Maja Djurisic1,
- Josh Syken3,
- Yang Dan2 and
- Carla J. Shatz1,†
- 1Department of Biology and Bio-X, James H. Clark Center, Stanford University, Stanford, CA 94305, USA.
- 2Division of Neurobiology, Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
- 3Vertex Pharmaceuticals Inc., Cambridge, MA 02139, USA.
- ↵†Corresponding author. E-mail: cshatz{at}stanford.edu
-
↵* These authors contributed equally to this work.
Science Translational Medicine 15 Oct 2014:
Vol. 6, Issue 258, pp. 258ra140
DOI: 10.1126/scitranslmed.3010157
Vol. 6, Issue 258, pp. 258ra140
DOI: 10.1126/scitranslmed.3010157
David N. Bochner
Department of Biology and Bio-X, James H. Clark Center, Stanford University, Stanford, CA 94305, USA.
Richard W. Sapp
Department of Biology and Bio-X, James H. Clark Center, Stanford University, Stanford, CA 94305, USA.
Jaimie D. Adelson
Department of Biology and Bio-X, James H. Clark Center, Stanford University, Stanford, CA 94305, USA.
Siyu Zhang
Division of Neurobiology, Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Hanmi Lee
Department of Biology and Bio-X, James H. Clark Center, Stanford University, Stanford, CA 94305, USA.
Maja Djurisic
Department of Biology and Bio-X, James H. Clark Center, Stanford University, Stanford, CA 94305, USA.
Josh Syken
Vertex Pharmaceuticals Inc., Cambridge, MA 02139, USA.
Yang Dan
Division of Neurobiology, Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Carla J. Shatz
Department of Biology and Bio-X, James H. Clark Center, Stanford University, Stanford, CA 94305, USA.
