Research ArticleSurgery

Clinical recovery from surgery correlates with single-cell immune signatures

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Science Translational Medicine  24 Sep 2014:
Vol. 6, Issue 255, pp. 255ra131
DOI: 10.1126/scitranslmed.3009701

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  • Predicting outcome is a challenge

    Gaudilliere and colleagues report a new and promising possibility to detect outcome risks for surgery in future. As they studied patients at a mean age of 59.5 years (y) with no comorbidities and an elective surgical procedure there is the question what this results mean for a clinical population, especially for the elderly patient with accidental trauma, to predict outcome. The gerontological value of the single-cell im...

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    Competing Interests: None declared.
  • Measuring surgical recovery

    This novel approach provides a specific cellular background to some of the previously explored biomarkers in response to surgery and it also measured in-vivo their specific cell signalling responses to a corresponding individual patient clinical recovery profile such as fatigue, functional impairment and pain respectively. Identifying such specific signalling responses in critical phenotypes defining clinical recovery a...

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    Competing Interests: None declared.