Research ArticlePreeclampsia

Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia

Science Translational Medicine  16 Jul 2014:
Vol. 6, Issue 245, pp. 245ra92
DOI: 10.1126/scitranslmed.3008808

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Misfolded Proteins in Preeclampsia

Preeclampsia is a disorder of pregnancy, which can cause a variety of complications or even death of the mother or infant. Its causes are not yet known, and there is no specific treatment other than delivering the baby, however premature it may be. Now, Buhimschi et al. have demonstrated that the placentas from women with preeclampsia contain clumps of misfolded protein, which may be causing the disease. Moreover, these misfolded proteins can also be detected in the patients’ urine, suggesting that it may be possible to detect early preeclampsia with a urine test.