Research ArticlePsoriasis

Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema

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Science Translational Medicine  09 Jul 2014:
Vol. 6, Issue 244, pp. 244ra90
DOI: 10.1126/scitranslmed.3008946

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Discrimination That’s Skin Deep

A molecular signature may be able to aid in the differential treatment of psoriasis from eczema. Quaranta et al. examined a group of individuals affected by both psoriasis and eczema and compared molecular signatures from psoriasis and eczema lesions on the same individual. This approach limited noise from interindividual variability, allowing the authors to focus on genes involved in disease pathogenesis. They found that psoriasis-specific genes involved not only immune mediators but also regulators of metabolism. In contrast, eczema-related genes included those related to the epidermal barrier and inflammasome activation. These insights provide not only new targets for disease-specific therapies but also an independently verified classifier that can be used in difficult to diagnose patients.