Research ArticleGraft-Versus-Host Disease

Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease

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Science Translational Medicine  02 Jul 2014:
Vol. 6, Issue 243, pp. 243ra87
DOI: 10.1126/scitranslmed.3008941

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Double Trouble Before Transplant

Graft-versus-host disease, a condition where transplanted immune cells attack the body of the transplant recipient, is a common complication of bone marrow or stem cell transplant. Although there are treatments available for treating graft-versus-host disease, they don’t always work well. Nalle et al. have now developed several different mouse models of this condition to provide insight into its causes. The authors used these mouse models to pinpoint two different ways that pretransplant conditioning contributes to graft-versus-host disease. This knowledge should help scientists search for new treatments against this disease, as well as identify safer ways to prepare patients for transplant.