Vol 6, Issue 243
- Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production
A humanized monoclonal antibody that targets the membrane IgE B cell receptor was associated with improvements in asthmatic airway responses.
Loss of TREM2 function impairs phagocytosis and correlates with decreased soluble TREM2 in biological fluids of patients with neurodegenerative disorders.
- Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease
Pretransplant conditioning promotes minor mismatch GVHD by causing intestinal barrier loss and depleting NK cells.
- Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
Neutralizing antibodies to HIV-1 envelope protect more effectively than an antibody to the CD4 cell receptor in rhesus macaques.