FocusCancer Genomics

Tumor Archaeology: Tracking Leukemic Evolution to Its Origins

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Science Translational Medicine  28 May 2014:
Vol. 6, Issue 238, pp. 238fs23
DOI: 10.1126/scitranslmed.3009168

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Unearthing of the BRAF mutation in self-renewing hematopoietic stem cells reveals an unexpected origin for hairy cell leukemia—a mature B cell malignancy—and a potential new therapeutic target (Chung et al., this issue).

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