Vol 6, Issue 231
Fibrosis resolution is impaired by aging and is mediated by altered cellular redox homeostasis because of a Nox4-Nrf2 imbalance that promotes an apoptosis-resistant myofibroblast phenotype.
In a feline model of lysosomal storage disease, intracranial gene therapy achieved therapeutic efficacy in the CNS and increased long-term survival.
- Immunological Visibility: Posttranscriptional Regulation of Human NKG2D Ligands by the EGF Receptor Pathway
Environmental changes induce human NKG2D ligand expression—immunological visibility—through the EGFR stress response.
Surface expression of inhibitory receptors such as PD-1 identifies the tumor antigen-specific CD8+ T cells that infiltrate melanoma.