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09 April 2014
Vol 6, Issue 231

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ONLINE COVER Turning Back the Clock. Lung tissue from old mice exposed to a compound that induces fibrosis contains an increased number of apoptosis-resistant myofibroblasts compared to lung tissue from young mice. Hecker et al. now show that these apoptosis-resistant cells contribute to an impaired ability of old mice to resolve tissue fibrosis. These investigators found that a change in redox homeostasis due to an increase in the enzyme Nox4 and a decrease in Nrf2, which mediates an antioxidant response, underlies the emergence of these apoptosis-resistant myofibroblasts and that targeting Nox4 in old mice improved fibrosis resolution. [CREDIT: ASHISH KURUNDKAR, UNIVERSITY OF ALABAMA AT BIRMINGHAM]