Contents

19 March 2014
Vol 6, Issue 228

About The Cover

Cover image expansion

ONLINE COVER Eliminate the Negative. The need for new antimicrobials is especially urgent for infections caused by Gram-negative bacteria, which have barriers that block penetration by drugs. Shown is the Gram-negative bacterium Acinetobacter baumannii, a short, rod-shaped (coccobacillus) opportunistic pathogen that infects people with compromised immune systems and is a recently recognized player in hospital-derived (nosocomial) infections. In this issue, Stavenger and Winterhalter describe the TRANSLOCATION project, a part of the Innovative Medicines Initiative's "New Drugs 4 Bad Bugs" venture that aims to find ways to help antibiotics breach Gram-negative bacteria's double-envelope defense. [CREDIT: DENNIS KUNKEL MICROSCOPY]