CommentaryPolicy

Making Prospective Registration of Observational Research a Reality

Science Translational Medicine  19 Feb 2014:
Vol. 6, Issue 224, pp. 224cm1
DOI: 10.1126/scitranslmed.3007513

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Abstract

The vast majority of health-related observational studies are not prospectively registered and the advantages of registration have not been fully appreciated. Nonetheless, international standards require approval of study protocols by an independent ethics committee before the study can begin. We suggest that there is an ethical and scientific imperative to publicly preregister key information from newly approved protocols, which should be required by funders. Ultimately, more complete information may be publicly available by disclosing protocols, analysis plans, data sets, and raw data.

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