About the Cover

19 February 2014
Vol 6, Issue 224

Cover image

Cover image expansion

ONLINE COVER The Tell-Tale Needle in the Haystack. This illustration shows a tumor shedding molecules of DNA into the bloodstream, where they can be detected and analyzed. Although the circulating tumor DNA (ctDNA) is easily identifiable in this image, the real-life scenario presents a challenge, with very rare molecules of ctDNA concealed in a large volume of normal blood. However, those molecules are there, and Bettegowda et al. now demonstrate that even early stage tumors in many different organs shed ctDNA that can be identified in a sample of the patient’s blood. In a related paper, Misale and coauthors show how information derived from ctDNA can be used to detect treatment-resistant colon cancer and demonstrate a method for overcoming this resistance. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]

About The Cover

Cover image expansion

ONLINE COVER The Tell-Tale Needle in the Haystack. This illustration shows a tumor shedding molecules of DNA into the bloodstream, where they can be detected and analyzed. Although the circulating tumor DNA (ctDNA) is easily identifiable in this image, the real-life scenario presents a challenge, with very rare molecules of ctDNA concealed in a large volume of normal blood. However, those molecules are there, and Bettegowda et al. now demonstrate that even early stage tumors in many different organs shed ctDNA that can be identified in a sample of the patient’s blood. In a related paper, Misale and coauthors show how information derived from ctDNA can be used to detect treatment-resistant colon cancer and demonstrate a method for overcoming this resistance. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]