Research ArticlePsoriasis

Integrative Biology Approach Identifies Cytokine Targeting Strategies for Psoriasis

Science Translational Medicine  12 Feb 2014:
Vol. 6, Issue 223, pp. 223ra22
DOI: 10.1126/scitranslmed.3007217

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Integrating Autoimmunity

True translational biology is a reciprocating process between observations of human disease and clinically relevant animal models. Neither alone is sufficient, but each builds off the other. Perera et al. use such an integrative approach to examine the role of interleukin-22 (IL-22) in psoriasis pathogenesis.

The authors found that injecting IL-22 into normal human skin grafts resulted in inflammatory changes that mimicked human psoriasis; these changes could be blocked with an IL-22–neutralizing antibody. They then took this a step further and through transcriptomic and bioinformatic analysis identified hub genes critical for the IL-22/psoriasis connection. One such hub gene, the serine/threonine kinase PIM1, was found to be a critical checkpoint for human skin inflammation and potential future therapeutic target in psoriasis.