PerspectiveMalaria

Piecing Together the Puzzle of Severe Malaria

Science Translational Medicine  13 Nov 2013:
Vol. 5, Issue 211, pp. 211ps18
DOI: 10.1126/scitranslmed.3007432

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Abstract

Severe malaria manifests as several overlapping syndromes with high mortality. Interaction of parasites with endothelial protein C receptors and high parasite biomass have recently been identified as key determinants of severe disease. However, gaps in our understanding of severe malaria might hinder translation of these findings into new therapies.

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