Vol 5, Issue 208
State of the Art Review
Successful treatment of pulmonary arterial hypertension requires better understanding of the disease, both clinically and mechanistically.
- Deep Brain Stimulation of the Midbrain Locomotor Region Improves Paretic Hindlimb Function After Spinal Cord Injury in Rats
Stimulating the midbrain improves gait and locomotion in rats with chronic spinal cord injury.
- Major Cancer Regressions in Mesothelioma After Treatment with an Anti-Mesothelin Immunotoxin and Immune Suppression
In patients with advanced chemotherapy-refractory mesothelioma, treatment with the anti-mesothelin immunotoxin SS1P and immunosuppression with pentostatin and cyclophosphamide resulted in marked and durable tumor regressions.
In subjects treated with an anesthetic, saturation of slow-wave activity in the EEG indicates the onset of thalamocortical isolation from the external world.
Antisense oligonucleotides can correct disease-specific phenotypes in cultured motor neurons differentiated from iPSCs derived from ALS patients with a C9ORF72 repeat expansion.