PerspectiveCancer Biomarkers

Going with the Flow: From Circulating Tumor Cells to DNA

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Science Translational Medicine  16 Oct 2013:
Vol. 5, Issue 207, pp. 207ps14
DOI: 10.1126/scitranslmed.3006305

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Molecular analyses of circulating tumor DNA (ctDNA) in plasma from cancer patients have the potential to deliver minimally invasive diagnostic and disease-monitoring biomarkers. Drawing from experience gained through the translation of circulating tumor cell detection to clinical tests, we discuss ctDNA as a source of tumor material for biomarker development.

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