LetterTuberculosis

Comment on “Community-Wide Isoniazid Preventive Therapy Drives Drug-Resistant Tuberculosis: A Model-Based Analysis”

Science Translational Medicine  25 Sep 2013:
Vol. 5, Issue 204, pp. 204le3
DOI: 10.1126/scitranslmed.3006386

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Abstract

Mills et al. recently used mathematical modeling to show that community-wide isoniazid preventative therapy may lead to a long-term increase in resistance at the population level. Although community-wide isoniazid preventive therapy may be useful in preventing tuberculosis (TB) in low-TB/HIV settings, isoniazid resistance is especially of concern in high TB/HIV populations.

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