Research ArticleDown Syndrome

Hedgehog Agonist Therapy Corrects Structural and Cognitive Deficits in a Down Syndrome Mouse Model

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Science Translational Medicine  04 Sep 2013:
Vol. 5, Issue 201, pp. 201ra120
DOI: 10.1126/scitranslmed.3005983

Article Information

vol. 5 no. 201 201ra120

PubMed: 
Print ISSN: 
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History: 
  • Received for publication February 21, 2013
  • Accepted for publication July 8, 2013

Author Information

  1. Ishita Das1,
  2. Joo-Min Park2,3,
  3. Jung H. Shin4,
  4. Soo Kyeong Jeon2,
  5. Hernan Lorenzi1,*,
  6. David J. Linden2,
  7. Paul F. Worley2 and
  8. Roger H. Reeves1,
  1. 1Department of Physiology and Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  2. 2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  3. 3Department of Physiology, Jeju National University School of Medicine, Jeju 690-756, South Korea.
  4. 4Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20857, USA.
  1. Corresponding author. E-mail: rreeves{at}jhmi.edu
  • * Present address: The J. Craig Venter Institute, Rockville, MD 20850, USA.

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