FocusGene Therapy

Vector Decoys Trick the Immune Response

Science Translational Medicine  17 Jul 2013:
Vol. 5, Issue 194, pp. 194fs28
DOI: 10.1126/scitranslmed.3006633

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Abstract

Humoral immunity to adeno-associated viral vectors can be overcome by using empty capsid mutant “decoys” for preexisting antibodies (Mingozzi et al., this issue).

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