LetterStem Cells

Comment on “Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells”

Science Translational Medicine  05 Jun 2013:
Vol. 5, Issue 188, pp. 188le2
DOI: 10.1126/scitranslmed.3005065

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Abstract

Egawa et al. recently showed the value of patient-specific induced pluripotent stem cells (iPSCs) for modeling amyotrophic lateral sclerosis in vitro. Their study and our work highlight the need for complementary assays to detect small, but potentially important, phenotypic differences between control iPSC lines and those carrying disease mutations.

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