FocusAutoimmune Disease

Autoantibodies: Double Agents in Human Disease

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Science Translational Medicine  22 May 2013:
Vol. 5, Issue 186, pp. 186fs19
DOI: 10.1126/scitranslmed.3006288

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Binding of cross-reactive autoantibodies to peptidylarginine deiminase 4 (PAD4) increases its activity by lowering its requirement for Ca2+, leading to increased production of citrullinated autoantigens and worse outcomes in patients with rheumatoid arthritis (Darrah et al., this issue).

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