Contents

27 March 2013
Vol 5, Issue 178

About The Cover

Cover image expansion

ONLINE COVER Bright Lights, Small Trials. The lights of Manhattan’s Times Square at night resemble color-coded data points that cluster on the basis of common traits. The numerous red points might represent patients with a common disease, and the other colors, patients with rare disorders or those who stratify into small disease subsets. Research on rare diseases and molecularly defined subgroups illuminates key aspects of human pathophysiology, and such advances in knowledge drive precision medicine. But as Korn et al. note in this week’s State of the Art Review, new treatments for rare diseases must be evaluated using special clinical trial designs and modes of analysis that address the statistical challenges associated with small sample sizes. [CREDIT: SEBASTIAN-JULIAN/ISTOCKPHOTO]