PerspectiveBIOMATERIALS

Acellular Biomaterials: An Evolving Alternative to Cell-Based Therapies

Science Translational Medicine  13 Mar 2013:
Vol. 5, Issue 176, pp. 176ps4
DOI: 10.1126/scitranslmed.3003997

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Abstract

Acellular biomaterials can stimulate the local environment to repair tissues without the regulatory and scientific challenges of cell-based therapies. A greater understanding of the mechanisms of such endogenous tissue repair is furthering the design and application of these biomaterials. We discuss recent progress in acellular materials for tissue repair, using cartilage and cardiac tissues as examples of applications with substantial intrinsic hurdles, but where human translation is now occurring.

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