Research ArticleCancer

Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects

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Science Translational Medicine  06 Feb 2013:
Vol. 5, Issue 171, pp. 171ra17
DOI: 10.1126/scitranslmed.3004828

Article Information

vol. 5 no. 171 171ra17

PubMed: 
Print ISSN: 
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History: 
  • Received for publication August 22, 2012
  • Accepted for publication December 28, 2012

Author Information

  1. Joshua E. Allen1,2,3,
  2. Gabriel Krigsfeld3,
  3. Patrick A. Mayes3,
  4. Luv Patel3,
  5. David T. Dicker1,3,
  6. Akshal S. Patel1,4,
  7. Nathan G. Dolloff1,3,
  8. Evangelos Messaris5,
  9. Kimberly A. Scata1,3,
  10. Wenge Wang1,
  11. Jun-Ying Zhou6,
  12. Gen Sheng Wu6 and
  13. Wafik S. El-Deiry1,2,3,7,*
  1. 1Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medicine (Hematology/Oncology), Penn State Hershey Cancer Institute, Hershey, PA 17033, USA.
  2. 2Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  3. 3Laboratory of Molecular Oncology and Cell Cycle Regulation, Departments of Medicine, Genetics, and Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  4. 4Department of Neurological Surgery, Penn State Hershey Medical Center, Hershey, PA 17033, USA.
  5. 5Department of Surgery, Penn State College of Medicine, Hershey, PA 17033, USA.
  6. 6Program in Molecular Biology and Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
  7. 7American Cancer Society, Atlanta, GA 30329, USA.
  1. *To whom correspondence should be addressed. E-mail: wafik.eldeiry{at}gmail.com

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