Contents
Vol 5, Issue 167
Contents
Perspective
- Repurposing the Pap Smear: One Step Closer to Gynecologic Cancer Screening
DNA testing has the potential to revolutionize screening and early detection of gynecologic malignancies.
Research Articles
- Evaluation of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers
Mutant DNA from ovarian and endometrial tumors can be detected in Pap smear specimens through massively parallel sequencing.
- Targeting the JMJD2 Histone Demethylases to Epigenetically Control Herpesvirus Infection and Reactivation from Latency
Inhibitors of cellular histone demethylases, enzymes required for herpesvirus infection, block early-stage infection and prevent reactivation from latency, demonstrating the potential benefit of epigenetic antiviral therapeutics.
- Human Cartilage Repair with a Photoreactive Adhesive-Hydrogel Composite
A photoactive hydrogel is used in combination with microfracture to heal cartilage defects in patients.
State of the Art Review
- Therapy for Fibrotic Diseases: Nearing the Starting Line
An emerging consensus indicates that fibrotic diseases in lung, liver, and kidney exhibit common underlying mechanisms, which can be targeted therapeutically.
Editors' Choice
- FcγRs Muscle Up Dendritic Cell Cross-Presentation
Targeting FCγ receptors may improve dendritic cell–mediated vaccination.
- Inspired by Porcupines
Porcupine quills inspire new design concepts for hypodermic needles.
- A Better Pacemaker: Transdifferentiation of Myocytes to Pacemaker Cells
Transdifferentiation of heart cells with a key transcription factor generates functional pacemaker cells in situ, a new approach to correcting heart failure.
- A Beacon of Danger
Seeking a better biomarker signature for predicting heart disease severity.
- SLITting Down the Peanut Allergy
Sublingual immunotherapy induced a modest level of desensitization in peanut allergy sufferers.
