Contents

07 November 2012
Vol 4, Issue 159
  • Contents

    • Commentary

      • Research Results: Preserving Newborn Blood Samples

        The debate about retention and use of dried blood samples from newborn screening ignores the harm destruction may cause to biomedical research.

    • Perspective

      • Improving Risk Assessment

        A U.S. government initiative to engineer nonclinical cell-based models that mimic human biology may improve predictions of drug-related adverse events.

    • Research Articles

      • A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

        An in vitro model of human pulmonary edema predicts drug toxicity and efficacy previously observed in humans.

      • An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

        Transient receptor potential vanilloid 4 (TRPV4) channels are expressed in human heart failure lungs, which can be blocked to prevent and resolve heart failure–induced pulmonary edema.

      • Human Melanoma Metastasis in NSG Mice Correlates with Clinical Outcome in Patients

        The ability of melanomas to produce circulating tumor cells and to metastasize in immunocompromised mice correlates with their ability to form distant metastases in patients.

    • Editors' Choice

      • Taking a Bite Out of Pain

        Peptides in black mamba snake venom exert powerful analgesic effects by blocking acid-sensing ion channels in the mammalian nervous system.

      • Milk of Amnesia

        The concentrations of the anesthetic propofol used clinically are not toxic to neural precursor cells in culture.

      • E-Selectin Gets HSCs Buzzing.

        E-selectin inhibition may protect HSCs from chemo- and radiotherapy.

      • Pomc to the Rescue

        Obesity-programmed mice are rescued by early genetic intervention.

      • Pneumonia Therapy Blazes a New TRAIL

        A therapy that induces programmed cell death in alveolar macrophages helps mice survive pneumonia.

      • Visible to the Naked Eye

        A plasmonic biosensor detects extremely low concentrations of diagnostic markers for prostate cancer and HIV.

About The Cover

Cover image expansion

ONLINE COVER Lung-on-a-Chip. Recreating human organs within microfluidic devices could further research on drug toxicity, pharmacology, and discovery. In this issue, Huh et al. developed a lung-on-a-chip in vitro model that mimicked the physiology of human lungs during pulmonary edema. As shown in the cover image, two elastic outer channels (green) "breathed" for the lung, while the center channel (blue) housed the air- and fluid-filled channels, representing lung and vasculature, respectively. The addition of an experimental drug—which is currently in preclinical testing in animals (Thorneloe et al., this issue)—stopped fluid leakage and restored the engineered lungs to normal. See a related Perspective by Dambach and Uppal. [CREDIT: WYSS INSTITUTE]