Research ArticleCancer

Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling

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Science Translational Medicine  24 Oct 2012:
Vol. 4, Issue 157, pp. 157ra143
DOI: 10.1126/scitranslmed.3004330

Article Information

vol. 4 no. 157 157ra143

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History: 
  • Received for publication May 17, 2012
  • Accepted for publication September 18, 2012

Author Information

  1. Yinyin Yuan1,2,*,,
  2. Henrik Failmezger3,4,,
  3. Oscar M. Rueda1,2,,
  4. H. Raza Ali1,2,,
  5. Stefan Gräf1,2,§,
  6. Suet-Feung Chin1,2,
  7. Roland F. Schwarz1,2,
  8. Christina Curtis5,
  9. Mark J. Dunning1,
  10. Helen Bardwell1,
  11. Nicola Johnson6,
  12. Sarah Doyle6,
  13. Gulisa Turashvili7,8,
  14. Elena Provenzano6,9,
  15. Sam Aparicio7,8,
  16. Carlos Caldas1,2,9,10 and
  17. Florian Markowetz1,2,*
  1. 1Cancer Research UK Cambridge Research Institute, Cambridge CB2 0RE, UK.
  2. 2Department of Oncology, University of Cambridge, Cambridge CB2 2XZ, UK.
  3. 3Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829 Cologne, Germany.
  4. 4Gene Center and Department of Biochemistry, Center for Integrated Protein Science Munich, Ludwigs-Maximilian University, Munich 81377, Germany.
  5. 5Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  6. 6Department of Histopathology, Cambridge University Hospital NHS Foundation Trust (Addenbrooke’s Hospital), Cambridge CB2 0QQ, UK.
  7. 7Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.
  8. 8Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
  9. 9Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK.
  10. 10Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK.
  1. *To whom correspondence should be addressed. E-mail: florian.markowetz{at}cancer.org.uk (F.M.); yinyin.yuan{at}icr.ac.uk (Y.Y.)
  • Present address: The Institute of Cancer Research, London SW3 6JB, UK.

  • These authors contributed equally to this work.

  • § Present address: Division of Respiratory Medicine, Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK.

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