PerspectivePreclinical Studies

Extrapolating from Animals to Humans

Science Translational Medicine  12 Sep 2012:
Vol. 4, Issue 151, pp. 151ps15
DOI: 10.1126/scitranslmed.3004631

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Abstract

Because of a variety of caveats, the safety and effectiveness of interventions in human subjects can only be speculated from animal studies. Careful synthesis of data from multiple animal studies is needed to begin to assess the likelihood of successful cross-species translation (Fay et al., this issue).

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