Research ArticleHIV

An Intravaginal Ring That Releases the NNRTI MIV-150 Reduces SHIV Transmission in Macaques

Science Translational Medicine  05 Sep 2012:
Vol. 4, Issue 150, pp. 150ra123
DOI: 10.1126/scitranslmed.3003936

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HIV Protection That Has a Ring to It

An ounce of prevention is better than a pound of cure. This is especially true for HIV, where no cure exists. Pre-exposure prophylaxis is showing promising results in preventing HIV transmission in early clinical trials, but the means of delivery of active pharmaceutical ingredients remains a major challenge. Singer et al. now show that the non-nucleoside reverse transcriptase inhibitor MIV-150 delivered by intravaginal rings can protect macaques from simian/HIV (SHIV) infection.

For pre-exposure prophylaxis to be successful, individuals must remember and be willing to treat themselves regularly. Intravaginal rings are well tolerated among women and—through sustained release—can help overcome this adherence bottleneck. The authors test the efficacy of MIV-150 when delivered by intravaginal rings made of either ethylene vinyl acetate or silicone. MIV-150 was successfully delivered to vaginal fluids and tissues and protected macaques from SHIV infection. If these studies hold true in people, intravaginal rings containing MIV-150 may help prevent HIV infection.