Research ArticleCerebrospinal Fluid Circulation

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

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Science Translational Medicine  15 Aug 2012:
Vol. 4, Issue 147, pp. 147ra111
DOI: 10.1126/scitranslmed.3003748

Article Information

vol. 4 no. 147 147ra111

PubMed: 
Print ISSN: 
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History: 
  • Received for publication January 20, 2012
  • Accepted for publication June 25, 2012

Author Information

  1. Jeffrey J. Iliff1,*,
  2. Minghuan Wang1,2,
  3. Yonghong Liao1,
  4. Benjamin A. Plogg1,
  5. Weiguo Peng1,
  6. Georg A. Gundersen3,4,
  7. Helene Benveniste5,6,
  8. G. Edward Vates1,
  9. Rashid Deane1,
  10. Steven A. Goldman1,7,
  11. Erlend A. Nagelhus3,4 and
  12. Maiken Nedergaard1,*
  1. 1Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
  2. 2Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  3. 3Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway.
  4. 4Centre for Molecular Biology and Neuroscience, Letten Centre, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
  5. 5Department of Radiology, Health Science Center, Stony Brook University, Stony Brook, NY 11794, USA.
  6. 6Department of Anesthesiology, Health Science Center, Stony Brook University, Stony Brook, NY 11794, USA.
  7. 7Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.
  1. *To whom correspondence should be addressed. E-mail: jeffrey_iliff{at}urmc.rochester.edu (J.J.I.); nedergaard{at}urmc.rochester.edu (M.N.)

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