Contents

18 July 2012
Vol 4, Issue 143

About The Cover

Cover image expansion

ONLINE COVER A Deadly Virus in Mother's Milk. Mammary duct of an HIV-infected woman showing T cells (blue) typically found in breast milk. Integrated HIV provirus (yellow rectangles) persists in the nuclei and many T cells are immunologically activated (pink cytoplasm), increasing their tendency to release HIV virions (yellow spheres). As described by Van de Perre et al. in a State of the Art Review in this issue, even when the mother is successfully treated with antiretroviral therapy, HIV from these sources in breast milk can penetrate the infant's intestinal wall, causing infection. In fact, HIV transmission to infants through breast-feeding is currently the largest contributor to new pediatric HIV infections. [CREDIT: B. STRAUCH/SCIENCE TRANSLATIONAL MEDICINE]