ReviewDeep Brain Stimulation

Deep Brain Stimulation for Psychiatric Disease: Contributions and Validity of Animal Models

See allHide authors and affiliations

Science Translational Medicine  11 Jul 2012:
Vol. 4, Issue 142, pp. 142rv8
DOI: 10.1126/scitranslmed.3003722

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Editor's Summary

Deep brain stimulation (DBS), in which an electrode is implanted permanently for stimulation of the brain, is used successfully to treat Parkinson’s disease. The method is being actively investigated for use in obsessive-compulsive disorder, depression, addiction, and other psychiatric diseases. This review outlines how stimulation of the brain in animals exhibiting analogs to these human pathological behaviors can model these applications of DBS and shows that results from these studies can help optimize DBS treatment and dissect its therapeutic mechanisms.