Research ArticleParkinson’s Disease

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease

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Science Translational Medicine  04 Jul 2012:
Vol. 4, Issue 141, pp. 141ra90
DOI: 10.1126/scitranslmed.3003985

Article Information

vol. 4 no. 141 141ra90

PubMed: 
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History: 
  • Received for publication 7 March 2012.
  • Accepted for publication 1 June 2012.

Author Information

  1. Oliver Cooper1,*,,
  2. Hyemyung Seo1,*,,
  3. Shaida Andrabi2,,
  4. Cristina Guardia-Laguarta3,,
  5. John Graziotto4,,
  6. Maria Sundberg1,,
  7. Jesse R. McLean1,,
  8. Luis Carrillo-Reid5,,
  9. Zhong Xie5,,
  10. Teresia Osborn1,,
  11. Gunnar Hargus1,,
  12. Michela Deleidi1,,
  13. Tristan Lawson1,,
  14. Helle Bogetofte1,,
  15. Eduardo Perez-Torres1,,
  16. Lorraine Clark3,,
  17. Carol Moskowitz3,,
  18. Joseph Mazzulli4,,
  19. Li Chen2,,
  20. Laura Volpicelli-Daley6,,
  21. Norma Romero3,,
  22. Houbo Jiang7,,
  23. Ryan J. Uitti8,,
  24. Zhigao Huang9,
  25. Grzegorz Opala10,
  26. Leslie A. Scarffe2,,
  27. Valina L. Dawson2,,
  28. Christine Klein11,
  29. Jian Feng7,,
  30. Owen A. Ross8,,
  31. John Q. Trojanowski6,,
  32. Virginia M.-Y. Lee6,,
  33. Karen Marder3,,
  34. D. James Surmeier5,,
  35. Zbigniew K. Wszolek8,,
  36. Serge Przedborski3,,
  37. Dimitri Krainc4,,
  38. Ted M. Dawson2, and
  39. Ole Isacson1,§
  1. 1Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA.
  2. 2Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, and Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  3. 3Departments of Neurology, Psychiatry, and Pathology and Cell Biology, Sergievsky Center, Taub Institute and the Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
  4. 4MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
  5. 5Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
  6. 6Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  7. 7Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA.
  8. 8Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  9. 9University of Florida Shands, Jacksonville, FL 32209, USA.
  10. 10Department of Neurology, Medical University of Silesia, Katowice 40-055, Poland.
  11. 11Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, 23562 Luebeck, Germany.
  1. §To whom correspondence should be addressed. E-mail: isacson{at}hms.harvard.edu
  • * These authors contributed equally to this work.

  • NINDS PD iPS Cell Research Consortium.

  • Present address: Department of Molecular and Life Sciences, Hanyang University, Ansan 426-791, South Korea.

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