FocusCancer

Resurrecting DNAzymes as Sequence-Specific Therapeutics

Science Translational Medicine  20 Jun 2012:
Vol. 4, Issue 139, pp. 139fs20
DOI: 10.1126/scitranslmed.3004080

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Abstract

In a mouse model of skin cancer, intratumoral injection of a sequence-specific mRNA-cleaving DNA enzyme caused potent inhibition of tumor growth and unusually benign pharmacodynamic profiles.

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