Microbiota, Disease, and Back to Health: A Metastable Journey

Science Translational Medicine  06 Jun 2012:
Vol. 4, Issue 137, pp. 137rv7
DOI: 10.1126/scitranslmed.3004184

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Alterations in the composition of the commensal microbiota have been observed in many complex diseases. Understanding the basis for these changes, how they relate to disease risk or activity, and the mechanisms by which the symbiotic state of colonization resistance and host homeostasis is restored is critical for future therapies aimed at manipulating the microbiota.

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