Contents
Vol 4, Issue 134
Contents
Editorial
- APOE ε4 Status and Traumatic Brain Injury on the Gridiron or the Battlefield
APOE ε4 carriers who experience traumatic brain injury are likely to have an increased risk of dementia, raising the question of whether APOE genotyping should be required for high school athletes or for prospective military personnel.
Perspective
- Drug-Based Optical Agents: Infiltrating Clinics at Lower Risk
Using drugs as optical imaging agents and “microdosing” amounts reduces risk for clinical translation of fluorescence molecular imaging.
Research Articles
- Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model
Blast exposure is associated with chronic traumatic encephalopathy, impaired neuronal function, and persistent cognitive deficits in blast-exposed military veterans and experimental animals.
- Gene Therapy for Aromatic l-Amino Acid Decarboxylase Deficiency
Gene therapy can restore some motor function in patients with aromatic l-amino acid decarboxylase deficiency.
- CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients
CD25 monoclonal antibody therapy rapidly and durably depletes Tregs in cancer patients through a mechanism consistent with reprogramming.
- High-Throughput Sequencing Detects Minimal Residual Disease in Acute T Lymphoblastic Leukemia
High-throughput sequencing can detect minimal residual disease comparable to multiparametric flow cytometry in T-ALL patients.
Editors' Choice
- A Tinier Target for B Cell Therapy in Multiple Sclerosis
Anti–IL-6 therapy may be an improved option for treatment of multiple sclerosis.
- Coming Unglued: The Potential to Break Apart Biofilms
Norspermidine targets certain matrix molecules to promote biofilm disassembly and prevent biofilm formation.
- You May Feel Some Discomfort—or Not!
Developing chronic pain might be a function of certain receptor mutation.
- Of Bugs and Men: Antibiotics, the Gut Microbiota, and Risk of Developing Allergic Asthma
Early-life antibiotic use can alter gut microbiota and enhance asthma susceptibility.
