CD4+ T Cells and HIV: A Paradoxical Pas de Deux

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Science Translational Medicine  29 Feb 2012:
Vol. 4, Issue 123, pp. 123ps4
DOI: 10.1126/scitranslmed.3003862

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When it comes to HIV infection, CD4+ T cells are usually thought of as the cells that are preferentially infected and killed by the virus. In a new study, Soghoian et al. now show that during the early stages of HIV infection, CD4+ T cells suppress virus replication and delay disease onset. Thus, the robustness of the CD4+ T cell response during early HIV infection could be used as a marker to determine the speed of disease progression. The new findings also have implications for the design of preventive and therapeutic AIDS vaccines.

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