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29 February 2012
Vol 4, Issue 123

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ONLINE COVER Go with the Flow. In healthy people, blood flows uninterrupted throughout the body. In patients with sickle cell disease, however, red blood cells take on a crescent shape that physically impedes the flow of blood. Wood et al. have created a microfluidic device that can measure such decreased flow velocity in blood samples from sickle cell patients. This biophysical indicator can then be used to stratify patients on the basis of disease severity and predict response to therapy. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]

About The Cover

Cover image expansion

ONLINE COVER Go with the Flow. In healthy people, blood flows uninterrupted throughout the body. In patients with sickle cell disease, however, red blood cells take on a crescent shape that physically impedes the flow of blood. Wood et al. have created a microfluidic device that can measure such decreased flow velocity in blood samples from sickle cell patients. This biophysical indicator can then be used to stratify patients on the basis of disease severity and predict response to therapy. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]