Research ArticleCancer

Activation of ERBB2 Signaling Causes Resistance to the EGFR-Directed Therapeutic Antibody Cetuximab

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Science Translational Medicine  07 Sep 2011:
Vol. 3, Issue 99, pp. 99ra86
DOI: 10.1126/scitranslmed.3002442

Article Information

vol. 3 no. 99 99ra86

PubMed: 
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History: 
  • Received for publication March 25, 2011
  • Accepted for publication July 15, 2011

Author Information

  1. Kimio Yonesaka1,2,3,4,
  2. Kreshnik Zejnullahu1,2,
  3. Isamu Okamoto3,
  4. Taroh Satoh3,
  5. Federico Cappuzzo5,
  6. John Souglakos6,7,
  7. Dalia Ercan1,2,
  8. Andrew Rogers1,2,
  9. Massimo Roncalli5,
  10. Masayuki Takeda3,
  11. Yasuhito Fujisaka3,
  12. Juliet Philips2,
  13. Toshio Shimizu3,
  14. Osamu Maenishi8,
  15. Yonggon Cho9,
  16. Jason Sun1,2,
  17. Annarita Destro5,
  18. Koichi Taira10,
  19. Koji Takeda10,
  20. Takafumi Okabe1,2,
  21. Jeffrey Swanson1,2,
  22. Hiroyuki Itoh8,
  23. Minoru Takada11,
  24. Eugene Lifshits12,
  25. Kiyotaka Okuno13,
  26. Jeffrey A. Engelman12,
  27. Ramesh A. Shivdasani2,14,
  28. Kazuto Nishio15,
  29. Masahiro Fukuoka4,11,
  30. Marileila Varella-Garcia9,
  31. Kazuhiko Nakagawa3,* and
  32. Pasi A. Jänne1,2,14,*
  1. 1Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  2. 2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  3. 3Department of Medical Oncology, Kinki University School of Medicine, Osaka 589-8511, Japan.
  4. 4Department of Medical Oncology, Izumi Municipal Hospital, Osaka 594-0071, Japan.
  5. 5Istituto Clinico Humanitas, Rozzano 20089, Italy.
  6. 6Laboratory of Tumor Biology, Medical School, University of Crete, Heraklion 71110, Greece.
  7. 7University Hospital of Heraklion, Heraklion 71110, Greece.
  8. 8Department of Pathology, Kinki University School of Medicine, Osaka 589-8511, Japan.
  9. 9University of Colorado Cancer Center, Aurora, CO 80045, USA.
  10. 10Department of Clinical Oncology, Osaka City General Hospital, Osaka 534-0021, Japan.
  11. 11Department of Medical Oncology, Kinki University School of Medicine, Sakai Hospital, Osaka 590-0132, Japan.
  12. 12Massachusetts General Hospital Cancer Center, Boston, MA 02129, USA.
  13. 13Department of Surgery, Kinki University School of Medicine, Osaka 589-8511, Japan.
  14. 14Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  15. 15Department of Genome Biology, Kinki University School of Medicine, Osaka 589-8511, Japan.
  1. To whom correspondence should be addressed. E-mail: nakagawa{at}med.kindai.ac.jp (K.N.); pjanne{at}partners.org (P.A.J.)

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