Research ArticleDrug Discovery

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

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Science Translational Medicine  17 Aug 2011:
Vol. 3, Issue 96, pp. 96ra76
DOI: 10.1126/scitranslmed.3002648

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  • Is a single type of data sufficient for accurate computational drug repositioning?

    Sir,

    We read with interest the article by Dudley et al, "Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease". The authors used a single type of data, namely public microarray data, to create gene expression signatures for drugs and diseases, and compared these signatures to arrive at novel repositioning candidates for Inflammatory Bowel Disease (IBD). They found topiramat...

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    Competing Interests: None declared.