PerspectiveHIV

Drug Effectiveness Explained: The Mathematics of Antiviral Agents for HIV

Science Translational Medicine  13 Jul 2011:
Vol. 3, Issue 91, pp. 91ps30
DOI: 10.1126/scitranslmed.3002656

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Antiretroviral therapy has improved the quality and length of life of millions of individuals affected by human immunodeficiency virus type 1 (HIV-1). The capacity of these drugs to indefinitely suppress HIV—which has a well-known capacity for escaping antiviral pressures—is surprising. In this issue of Science Translational Medicine, Shen et al. use a combination of mathematical modeling and experiment to examine the potency of anti-HIV drugs. They show that non-nucleoside reverse transcriptase inhibitors and protease inhibitors exhibit cooperative dose-response curves—a finding that has implications for the treatment of HIV as well as other viral infections, such as hepatitis C.

Footnotes

  • Citation: A. S. Perelson, S. G. Deeks, Drug Effectiveness Explained: The Mathematics of Antiviral Agents for HIV. Sci. Transl. Med. 3, 91ps30 (2011).

View Full Text