PerspectiveVaccine Design

Vaccine Design Reaches the Atomic Level

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Science Translational Medicine  13 Jul 2011:
Vol. 3, Issue 91, pp. 91ps29
DOI: 10.1126/scitranslmed.3002807

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The genetic diversity of pathogens presents a challenge to the development of broadly effective vaccines. In this issue, Scarselli et al. combine atomic-level structural information with genomics and classical vaccinology to design a single immunogen that elicits protective immunity against more than 300 natural variants of the bacterial pathogen meningococcus B. This accomplishment provides a glimpse of the power of structure-based vaccine design to create immunogens capable of eliciting protective responses against genetically diverse pathogens.


  • Citation: P. D. Kwong, L. Shapiro, Vaccine Design Reaches the Atomic Level. Sci. Transl. Med. 3, 91ps29 (2011).

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